Questions and answers in the management of primary central nervous system and ocular lymphomas.

of 3.5-5 months. Historically, radiotherapy alone has been the standard treatment for PCNSL; however, radiotherapy is rarely a curative treatment in PCNSL patients since response is usually short-lived, with a median survival of 12-14 months.12,13 Moreover, the positive impact of chemotherapy progressively limited the indications for radiotherapy alone. Current therapeutic knowledge in PCNSL results from a limited number of non-randomized phase-II trials,14 meta-analyses of published series13,15 and large retrospective, multicenter series.2 Despite the fact that literature on PCNSL has been progressively increasing, several therapeutic questions remain unanswered, and the use of divergent study designs and entry criteria lead to incomparable results and debatable conclusions.14 The present article summarizes the most relevant open questions in PCNSL treatment, and analyzes the related literature to identify the most reliable answers.